Research Discovery

A protocol briefing on prospective surveillance, tissue collection, and multiomic risk profiling for pleural mesothelioma evolution. (pmid:42386348)

A preliminary laboratory study compared Arthrospira platensis-derived samples against Giardia duodenalis cysts and found the simulated digestion product had the lowest reported IC50 among the tested samples. These findings are hypothesis-generating only and do not demonstrate a human treatment effect.

A rat experiment found that liquid-diet delivery route and pectin type were associated with distinct fecal and gut-microbiota measures. The study is useful for hypothesis generation, but it does not establish human clinical effects.

A retrospective machine-learning study evaluated whether AML gene-expression profiles can recover missing global IDH mutation annotations in public datasets.

A 2026-06-11 methods study describes LIET-EMG, Mu_Counts, and TFEA-LE for measuring differentially transcribed regulatory elements and identifying likely upstream transcription-factor regulators.

A study protocol outlines a planned multimodal experiment comparing brief mindfulness, relaxation, and podcast conditions in adults with depression and adult ADHD.

A meeting report describes how RNAmed’s 2025 retreat used cross-disciplinary training and discussion to examine RNA-therapy topics and shared development priorities.

A single-center serum metabolomics study found different exploratory metabolic patterns across two burn-size groups, but it did not validate a clinical test or demonstrate effects on outcomes.

An explainer of an essay on why ethical governance should be built into organ-chip research and commercialization from the outset.

A protocol describes how the Amyloidosis Center Charité Berlin plans to assemble longitudinal, interdisciplinary data for observational and translational research in systemic amyloidosis.

A research explainer of a graph-based framework for drug–drug interaction analysis, its reported benchmark metrics, and the limits of interpreting those results.

A 2026-06-09 integrative myocardial-transcriptomics study prioritized seven dilated cardiomyopathy molecular candidates. Four had consistent external support, while three remained exploratory; the work is tissue-level and hypothesis-generating rather than a clinical test.

Two preclinical studies connect distinct cholesterol routes to stem-like behavior and 5-fluorouracil resistance in colorectal cancer, while leaving their relationship in human tumors unresolved.

Three studies separate how acute myeloid leukemia stem-like cells are identified, what lets them self-renew, and which states persist after chemotherapy.

Three primary studies show why cognitive endpoints in mitochondrial disease must distinguish cognitive change from motor speed, fatigue, baseline ability, practice effects, and phenotype.

Two recent studies use different perturbations to place microglia inside causal chains of experimental brain injury: NREP-linked inflammatory polarization after ischemia and complement-linked synapse engulfment in a Parkinson's disease model.

Two mouse studies show why viral myocarditis research needs both sensitive longitudinal measurement and carefully bounded mechanism tests.

A new human tissue classification reveals five structural forms of peritoneal adhesions. An independent mechanistic study suggests that early neutrophil DNA scaffolds may help initiate the tissue organization that follows, but that connection remains untested in patients.

A new patient subgroup analysis and a separate cell study narrow the case for PIK3CA as an aspirin-response marker in colorectal cancer. Their convergence is biologically informative, but the patient evidence remains imprecise and the metabolic mechanism is preclinical.

Two mouse studies examine cardiorenal crosstalk from opposite directions: how chronic kidney disease changes the heart after infarction, and how infarction changes kidney signaling over time.

A fresh registry cluster analysis and an independent quantitative-CT cohort show that alpha-1 antitrypsin deficiency does not produce one uniform lung phenotype.

A fresh human pancreatic-lesion study and an independent patient-derived cell study connect cholesterol-pathway markers with sharply heterogeneous responses to statin perturbation, without establishing a clinical intervention.

Two recent studies show that functional precision oncology needs both representative patient-derived tumor models and validated assays that distinguish early drug effects from durable growth control.

Three recent primary studies show that genetic variants, serum microRNAs, and plasma metabolites answer different biomarker questions in Parkinson disease.

A 1,152-patient breast-cancer transcriptomics resource and a separate survival-analysis workflow show how stage patterns and outcome associations can be investigated as distinct, complementary layers.

The ENCODE project set out to catalog the functional elements of the human genome — the switches and regulators beyond protein-coding genes — reshaping how the genome is read.

The Wellcome Trust Case Control Consortium scanned 14,000 cases across seven common diseases, showing genome-wide association could find disease-linked variants.

A draft 'pangenome' from 47 diverse people captures variation the decades-old single reference missed — pointing to fairer, more complete disease genetics as an emerging direction.

In 2022 researchers finished the human genome end to end, filling the ~8% the original reference had left as gaps for two decades.